STN-DBSの次は...: The 12th International Congress of Parkinson's Disease and Movement Disorders

The 12th International Congress of Parkinson's Disease and Movement DisordersのOpening Symposiumとして、Infusion therapy and surgery for Parkinson's diseaseがありました。Apomorphineやlevodopaの注射はそのうち日本にも入ってくるのでしょうね。
 Emory UniversityのRobert E. Gross先生からは、"Deep brain stimulation-Exploring new target"という題で、STN-DBSの次のターゲットのお話がありました。精神症状などのSTN-DBSの限界があり、GPiの見直し、PPNやZi、CMなどのtrialが紹介されました。
参考文献
Alessandro Stefani, Andres M. Lozano, Antonella Peppe, Paolo Stanzione, Salvatore Galati, Domenicantonio Tropepi, Mariangela Pierantozzi, Livia Brusa, Eugenio Scarnati, and Paolo Mazzone; Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain, June 2007; 130: 1596 - 1607.
Alessandro Stefani, Andres Lozano, Paolo Stanzione, and Paolo Mazzone; Targeting human PPN: few patients, numerous disputes. Brain, September 2007; 130: e80.
Plaha, Puneeta and Gill, Steven S.; Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease. Neuroreport. 16(17):1883-1887, November 28, 2005.
Kitagawa M, Murata J, Uesugi H, Kikuchi S, Saito H, Tashiro K, Sawamura Y; Two-year follow-up of chronic stimulation of the posterior subthalamic white matter for tremor-dominant Parkinson's disease. Neurosurgery. 2005 Feb;56(2):281-9; discussion 281-9.
Yoland Smith, Dinesh V. Raju, Jean-Francois Pare and Mamadou Sidibe; The thalamostriatal system: a highly specific network of the basal ganglia circuitry. Trends in Neurosciences Volume 27, Issue 9, September 2004, Pages 520-527

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